Orthobiology

www.orthobiology.ch

Orthobiologics

PRP - Shoulder	PRP - Elbow	PRP - Hand	PRP - Finger
PRP - Tenosynovitis stenosans	PRP - Carpal tunnel	PRP - De Quervain

PRP - Muscle	PRP - Repair	PRP - Nerve	PRP - Tendon
PRP - Cartilage

Linked-in C. Centeno	Linked-in J. Devereaux	PRP Infographic RCT Centeno	Linked-in Dr. A. Schek

PRP - Hip	PRP - Knee	PRP - Foot	PRP - Ankle

    Platelet Rich Plasma Injection Randomized Controlled Trials-2026

    Platelets are the driving force behind the PRP which contain over a thousand proteins and up to 1500 actual bioactive factors.
        [Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA. Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012;28(3):429-439. doi:10.1016/j. arthro.2011.10.018]

        Platelet-rich plasma has 7 essential proteins: platelet-derived growth factor (PDGF), transforming growth factor b (TGF-B), vascular
       endothelial growth factor (VEGF), epidermal growth factor, insulin-like growth factor, fibroblast growth factor, fibrin, fibronectin, and
        vitronectin. [Pavlovic V, Ciric M, Jovanovic V, Stojanovic P. Platelet rich plasma: a short overview of certain bioactive components. Open Med. 2016;11(1):242-247. doi:10.1515/med-2016- 004 ]

       Effects (selected): chondrocyte proliferation and differentiation, reduce cartilage breakdown, introduce adult mesenchymal stem cells to the
     area, promote anti-inflammation, promote the formation of synoviocytes that secrete hyaluronic acid, and act as a scaffold for cellular
   repair, reduce synovial inflammation and mitigation of cartilage deterioration.
        [Cottom JM, Verdoni TJ. Orthobiologics in the Foot and Ankle: An Update on the Current Literature. Foot Ankle Spec. 2025 Nov 1:19386400251382280. doi: 10.1177/19386400251382280]

        - LR-PRP for soft tissue injuries such as tendonitis/tendinosis: IL-1 Ra, IL-4, IL-8= antiinflammatory; MMP-9 = chondrotoxic. LR-PRP is
          more effective in regulating inflammation and promoting angiogenesis compared with LP-PRP
        - LP-PRP for intra-articular injections: does not express MMP-9